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200 mg. of Zen to my cart! 200 mg of
Zen: GABA is the
major inhibitory neurotransmitter in the brain and is active at 20% of CNS
synapses. As an inhibitory mediator in the brain, GABA, via its neuronal A
receptor, inhibits neurons by causing an influx of chloride ions. The
anxiolytic, muscle relaxant, and sedative effects of the benzodiazepines,
e.g. Librium and Valium, rely upon the facilitation of this chloride influx
initiated by GABA. There is evidence that anxiety and panic disorders are
associated with excessive neuronal activity consequent to a decrease in
GABA's function as an inhibitory mediator. The adverse psychological signs
associated with premenstrual syndrome may be due to a dysregulated
sensitivity of GABA receptors.
GABA
also stimulates human growth hormone (HGH) secretion. Studies with oral
administration of sodium valproate (an enhancer of endogenous GABA activity)
and the muscle relaxant Baclofen (an agonist of the GABA B receptor)
demonstrate their ability to stimulate increased HGH levels.
Theanine (glutamic acid gamma-ethylamide)
an amino acid derivative found naturally in tea (Camellia sinensis) is also
recognized as having calming properties. Human studies have demonstrated
that dietary theanine supplementation increases alpha wave activity,
fostering a state of alert relaxation. Animal studies have also shown that
administration of theanine regulates brain serotonin concentration by
affecting either serotonin synthesis or degradation in the brain. It has
been hypothesized that serotonin facilitates general and conditioned anxiety
at the level of medial temporal lobe structures. Although the calming effect
of this tea component may seem contradictory to the stimulatory properties
of tea's caffeine content, research suggests that theanine exerts an
antagonistic effect on caffeine's stimulatory action.
Also see this article:
Zen
in a Bottle: The Anti-Stress Effects of L-Theanine
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