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Allergy Research Group Search All Allergy Research Group  Products The Most Popular: Nattokinase ProGreens Germanium  Artemisinin	Allergy Research Group ®   VascuStatin A breakthrough in angiogenesis inhibition - 100 times stronger than shark cartilage. VascuStatin supports the human body in potentially reducing vascular formations associated with certain conditions of reduced metabolism, diminished immunity and mutating cells. Formation of new blood vessels is well-known to play a crucial role in tumor survival and growth. Several agents that act as angiogenesis inhibitors are currently being investigated as anti-tumor agents.    See Ingredients. The active ingredient of VascuStatin: PGM (proteoglycan mixture), a non-toxic extract of the plant Convolvulus Arvensis (bindweed), is one of those agents. Highly recommended for use in conjunction with Imm-Kine The research results are impressive and compelling: Anti-Angiogenesis Properties of a Common Weed -Convolvulus Arvensis Learn Even More About Vascustatin   Vascustatin                                     Product#: 74120-arg    120 total capsules per bottle      Each capsule contains:        250 mg   Bindweed                      (Convolvulus Arvensis) leaves extract                   Other ingredients:  Maltodextrin   Suggested Use: As a dietary supplement, one capsule once daily with a meal, or as directed by a healthcare practitioner.           Back to Top of Page		Search for products Customer Service    Questions? Fax order form fax: 828-225-8859 View Cart Checkout

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What The Manufacturer Says:

VascuStatin dietary supplement from Allergy Research Group® contains a significant quantity of leaf extract of bindweed (Convolvulus arvensis)

VascuStatin provides a potent and immune stimulating dietary ingredient, proteoglycan mixture (PGM).

VascuStatin's PGM in combination with proper nutrition enhances the immune system's ability to maintain good health, resist disease and inhibit angiogenesis.

Native Americans have traditionally used plants like bindweed (Convolvulus arvensis) to treat skin ulcers, reducing wound inflammation and swelling. Today we recognize that bindweed's traditional anti-inflammatory use on skin wounds may involve its component proteoglycans. The proteoglycan mixture (PGM) found in bindweed has now demonstrated potential for supporting the body in inhibiting angiogenesis.

Allergy Research Group's® VascuStatin contains a non-toxic extract of bindweed leaf rich in PGM. Recent studies using the chicken egg chorioallantoic membrane assay showed that PGM inhibited angiogenesis in a dose dependent manner. PGM also significantly inhibited abnormal cellular growth in a mouse model. PGM's effectiveness was apparent with oral, subcutaneous, intravenous, or intraperitoneal routes of administration.

PGM has also demonstrated potent immune stimulating properties. Lymphocyte proliferation and phagocyte activity increased with PGM administration in a recent in vitro study. Through range of concentration medium of 0 to 100 mcg/ml of PGM, lymphocyte proliferation and activity increased 46 to 85%, respectively.

PGM's effectiveness may depend upon its ability to disrupt the biological balance between the specific cytokines, such as interleukin 8 and platelet activating factor 4, respectively. Excess secretion of cytokines from specific cells can speed their neovascularization, and growth. Proteoglycan proteins can bind and inactivate the above mentioned cytokines. PGM may provide an effective adjunctive support to conventional medical therapy by promoting the host's own immune defenses.

It is highly recommended to consider combing Vascustatin with Imm-Kine for maximum positive effect.

 

How Your Patients May Benefit from VascuStatin, dietary supplement:

• Maintains healthy immune system status*

• Helps improve phagocytic activity

• Helps stimulate lymphocyte proliferation

• Promotes effective immune response to maintain healthy cellular growth

• May potentially assist in supporting the inhabitation of angiogenisis

References

• Anderson KC. Advances in disease biology: Therapeutic implications. Semin Hematol 2001;38:6-10.

• Dupont E, Savard PE, Jourdain C, et al. Antiangiogenic properties of a novel shark cartilage extract: potential role in the treatment of psoriasis. J Cutan Med Surg 1998;2:146-52.

• Folkman J. Angiogenesis research: from laboratory to clinic. Forum (Genova) 1999;9:59-62.

• Gonzalez S, Alcaraz MV, Cuevas J, et al. An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res 2000;20:1567-75.

• Hagedorn M, Zilberberg L, Lozano RM, et al. A short peptide domain of platelet factor 4 blocks angiogenic key events induced by FGF-2. Faseb J 2001;15:550-2.

• Klepacek I, Smetana K, Jr., Stol M. Changes in vascular pattern of chicken chorioallantois after cartilaginous extract, chondroitin sulfate and dextran sulfate treatment. Folia Biol 1993;39:51-4.

• Marsden ER, Hu Z, Fujio K, et al. Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. Lab Invest 1992;67:427-33.

• Palmer K, Hitt M, Emtage PC, et al. Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity. Gene Ther 2001;8:282-90.

• Riordan N, Meng X, Riordan H. 2000. Anti-angiogenic, anti-tumor and immunostimulatory effects of a non-toxic plant extract (PGM), Comprehensive Cancer Care 2000, Arlington, Virginia.

• Stander M, Naumann U, Wick W, et al. Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. Cell Tissue Res 1999;296:221-7.

• Strieter RM, Polverini PJ, Arenberg DA, et al. Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. J Leukoc Biol 1995;57:752-62.

• Yoneda J, Killion JJ, Bucana CD, et al. Angiogenesis and growth of murine colon carcinoma are dependent on infiltrating leukocytes. Cancer Biother Radiopharm 1999;14:221-30.

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